Home Page Biographical Sketch Awards & Distinctions Intellectual Property Advisory 
Boards
Invited Presentations National & International Activities Publications List & Index Books

    
Thomas Tobin
     Intellectual Property/Patents/Opinions/Licenses/Royalties

 
1. 1984: US Patent # 4,473,640, awarded, September 25, 1984. Detection of morphine and its analogues using enzymatic hydrolysis.

2. International Diagnostic Systems, 1987-1989; Royalty arrangements for fentanyl, carfentanil, furosemide, acepromazine, cocaine, detomidine, phenylbutazone, alfentanil, sufentanil and 20-plus others, in ELISA and PCFIA format

3. WTT ELISA TESTS. 1992. Founder with David Watt and Dan Tai of 'Spin Off' company to distribute ELISA tests for use in racing horses and greyhounds. Sold to Neogen Corp, 1991. Tests developed and brought to market include:
  • Generic Barbiturate
  • Generic Benzodiazepine
  • Generic Bronchodilator
  • Generic Corticosteroid
  • Generic Fentanil
  • Generic Opiate 1
  • Generic Promazine
  • Generic Tricyclics
  • Azaperone
  • Boldenone
  • Butorphanol
  • Clenbuterol
  • Cocaine &
           Benzoylecgonine
  • Detomidine &
           Medetomidine
  • Dexamethasone
  • Droperidol
  • Ethacrynic Acid
  • Etorphine
  • Flunixin
  • Glycopyrrolate
  • Haloperidol Metabolites
  • Isoxsuprine
  • Levallorphan
  • Lofentanil
  • Mazindol Metabolites
  • Cotinine
  • Methocarbamol
  • Phencyclodine
  • Prazepam
  • Sulfamethazine
  • Temazepam
  • Triamcinolone Acetonide
  • Meperidine
  • Mepivacaine
  • Nalbuphine
  • Oxymorphone
          Oxycodone
  • PCP
  • Pentazocine
  • Procaine
  • Stanozolol
  • Sulfamethazine
  • Tetracaine
  • Alfentanil
  • Bumetanide
  • Buprenorphine
  • Carfentanil
  • Fentanyl
  • Fluphenazine
  • Furosemide (Lasix)
  • Haloperidol (Blood only)
  • Mazindol (Sanorex)
  • Methylprednisolone
  • Nandrolone
  • Phenylbutazone
           (Blood only)
  • Reserpine
  • Sufentanil
  • THC Metabolites
  • Trans-3-hydroxycotinine
  • Anileridine
  • Azaperone
    3,4-aminobenzoyl-
        ecgonine
        (cocaine metab.)
  • Caffeine
  • Clenbuterol
  • Cromolyn
          (adapted)
  • Diprenorphine
  • Droperidol
  • Glycopyrrolate
           (adapted)
  • Imipramine
  • Isoxsuprine
  • Ketorolac
  • Lidocaine
  • Lofentanil
  • Mazindol
  • Medetomidine
  • Meperidine
  • Mepivacaine

4. 1981, 1995: Publishing royalties:  “Drugs and the Performance Horse, 1981” and “Equine Drugs and Vaccines:  A Guide for Owners and Trainers, 1995.”

5. 1999: US Patent #5,883,095, Formulations and methods to treat and prevent Equine Protozoal Myeloencephalitis. Investigational New Animal Drugs: two fast track / no environmental risk INADs for two agents for use in EPM.  US Patent #5,883,095 granted in this area; licensed to Bayer Animal Health, 1999, marketed as Marquisâ, August, 2001, first FDA approved treatment for EPM, significant UK and Kentucky royalty. 

            6. 2003: Copyright: Unusual mathematical analysis and biologically unique pathogenesis of MRLS copyrighted, US Copyright (US Copyright# TXU1111484).. 

7. 2006: US Patent # 7,074,834, Patent Awarded: “Long acting, reversible veterinary sedative and analgesic and method of use. A novel veterinary sedative and tranquilizer.” 

8
.   1999: Equine Drug Metabolite Standards, Certified Reference Standards, Stable Isotope Internal  Standards and Haptens: W. Karpiesiuk, F. Lehner, Eisenberg, R and Tobin, T have synthesized, purified and have licensed or are licensing the release as authentic equine metabolites/forensic standards or haptens, modest UK royalty: 

 

Parent Medication

Regulatory Analyte/
Internal Standard

1

Acepromazine

(metabolite)

1-Hydroxyethyl) promazine

2

Acepromazine

(deuterated metabolite)

D4 2-(1-hydroxyethyl) promazine

sulfoxide

3

Acepromazine

(metabolite)

Acepromazine sulfoxide

4

Amitraz

(deuterated metabolite)

D6 N-2,4-Dimethylphenyl-N’-methylformamidine

5

Bupivacaine (metabolite)

3-Hydroxybupivacaine

6

Chlorpromazine

(metabolite)

7-Hydroxychlorpromazine

7

Clenbuterol

(deuterated standard)

D9 Clenbuterol

8

Clenbuterol ( metabolite )

1-(4-Amino-3,5-Dichlorophenyl)ethane-1,2-diol

9

Clenbuterol (metabolite)

2-(2-)4-Amino-3,5-Dicholorophenyl)-2-hydroxyethylamino)-2-Methyl-Propan-1-Ol

10

Colterol and Bitolterol

(metabolite)

3-O-Methylcolterol

11

Carboxydetomidine

D4 Carboxydetomidine

12

Hydroxydetomidine

D4 Hydroxydetomidine

13

Fluphenazine

(metabolite)

7-Hydroxyfluphenazine

14

Furosemide

(deuterated standard)

D5 Furosemide

15

Flunixin

 (deuterated standard)

D3 Flunixin

16

Guafenesin

(deuterated standard )

D4 Guafenesin

16

Guanabenz (metabolite)

Hydroxyguanabenz

17

Ketoprofen

(deuterated standard )

D4 Ketoprofen

18

Lidocaine

(deuterated metabolite)

D10 3-hydroxylidocaine

19

Lidocaine (metabolite)

3-Hydroxylidocaine

20

Mazindol (metabolite)

2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxy-2,3-dihydro-isoindol-1-one

21

Mepivacaine

(deuterated metabolite)

D3 3-Hydroxymepivacaine

22

Mepivacaine (metabolite)

3-Hydroxymepivacaine

23

Methocarbamol

(deuterated metabolite)

D4 Methocarbamol

24

Phenylbutazone

(deuterated metabolite)

D9 Phenylbutazone

25

Procaine 

(deuterated metabolite)

D10 Procaine

26

Promazine (metabolite)

3-Hydroxypromazine

27

Promethazine

(metabolite)

Promethazine sulfoxide

28

Propanolol (metabolite)

4-Hydroxypropanolol

29

Propiomazine

(metabolite)

2-(1-Hydroxypropyl) promethazine sulfoxide

30

Propionylpromazine

(metabolite)

2-(1-Hydroxypropyl) promazine sulfoxide

31

Pyrilamine

(deuterated standard)

D4 Pyrilamine

32

Pyrilamine (metabolite)

O-desmethylpyrilamine

33

Ropivacaine (metabolite)

3-Hydroxyropivacaine

34

Ropivacaine (metabolite)

4-Hydroxyropivacaine

35

Selegiline (metabolite)

Desmethylselegiline

36

Tramadol (metabolite)

Desmethyltramadol

37

Tripelennamine

(metabolite)

3-OH-tripelennamine

38

 Nandrolone

D3 Nandrolone

 

9. 2011: Frontier BioPharm, License, March 2011, Compounds synthesized in cooperation with Frontier Biopharm LLC and transferred under license to Frontier Biopharm LLC as of August 24th 2011:

 

1

4-OH xylazine    

2

Hydroxyethylpromazine sulfoxide maleate salt (HEPS)

3

D4-Hydroxyethylpromazine sulfoxide (D4-HEPS)

4

3-Hydroxydetomidine HCl

5

3-Hydroxymepivacaine HCl

6

D4-3-Hydroxydetomidine HCl

7

3-Carboxydetomidine HCl

8

D4-3-Carboxydetomidine HCl

9

D5-Furosemide

10

4-Hydroxymepivacaine

11

D4-Guaifenisin

12

D4-Methocarbamol

13

Inositol-Tris-PyroPhosphate sodium salt (ITPP)