- Detection of morphine and its analogues using enzymatic
hydrolysis. G.A.U. 172, Serial #348,719.
- Radio-iodinated analog of fentanyl. Patent applied for, 1987.
- Licensing arrangements and/or antibody sale for radioimmunoassay
tests for fentanyl and etorphine, negotiated, 1987.
- Royalty arrangements for fentanyl, carfentanil, furosemide,
acepromazine, cocaine, detomidine, phenylbutazone, alfentanil,
sufentanil and 20-plus others, in ELISA and PCFIA format,
International Diagnostic Systems, 1987-1988.
- WTT ELISA TESTS. 1992. Founder with David Watt and Dan Tai of
'Spin Off' company to distribute ELISA tests for use in racing
horses and greyhounds. Sold to Neogen Corp, 1991. Tests developed
and brought to market include:
- Generic Barbiturate
- Generic Benzodiazepine
- Generic Bronchodilator
- Generic Corticosteroid
- Generic Fentanil
- Generic Opiate 1
- Generic Promazine
- Generic Tricyclics
- Azaperone
- Boldenone
- Butorphanol
- Clenbuterol
- Cocaine &
Benzoylecgonine
- Detomidine &
Medetomidine
- Dexamethasone
- Droperidol
- Ethacrynic Acid
- Etorphine
- Flunixin
- Glycopyrrolate
- Haloperidol Metabolites
- Isoxsuprine
- Levallorphan
- Lofentanil
- Mazindol Metabolites
- Cotinine
|
- Methocarbamol
- Phencyclodine
- Prazepam
- Sulfamethazine
- Temazepam
- Triamcinolone Acetonide
- Meperidine
- Mepivacaine
- Nalbuphine
- Oxymorphone
Oxycodone
- PCP
- Pentazocine
- Procaine
- Stanozolol
- Sulfamethazine
- Tetracaine
- Alfentanil
- Bumetanide
- Buprenorphine
- Carfentanil
- Fentanyl
- Fluphenazine
- Furosemide (Lasix)
- Haloperidol (Blood only)
- Mazindol (Sanorex)
- Methylprednisolone
|
- Nandrolone
- Phenylbutazone
(Blood only)
- Reserpine
- Sufentanil
- THC Metabolites
- Trans-3-hydroxycotinine
- Anileridine
- Azaperone
3,4-aminobenzoyl-
ecgonine
(cocaine metab.)
- Caffeine
- Clenbuterol
- Cromolyn
(adapted)
- Diprenorphine
- Droperidol
- Glycopyrrolate
(adapted)
- Imipramine
- Isoxsuprine
- Ketorolac
- Lidocaine
- Lofentanil
- Mazindol
- Medetomidine
- Meperidine
- Mepivacaine
|
Equine Drug Metabolite Standards:
W. Karpiesiuk, F. Lehner and TT have synthesized,
purified and licensed the release as authentic equine
metabolites/forensic standards or haptens:
|
No |
Metabolite/Deuterated Standard |
Parent Drug |
Remarks |
|
1. |
3-Hydroxylidocaine |
Lidocaine |
Metabolite |
|
2. |
4-Hydroxylidocaine |
Lidocaine |
Metabolite |
|
3. |
3-Hydroxymepivacaine |
Mepivacaine |
Metabolite |
|
4. |
4-Hydroxymepivacaine |
Mepivacaine |
Metabolite |
|
5. |
3-Hydroxybupivacaine |
Bupivacaine |
Metabolite |
|
6. |
3-Hydroxyropivacaine |
Ropivacaine |
Metabolite |
|
7. |
4-Hydroxyropivacaine |
Ropivacaine |
Metabolite |
|
8. |
O-Desmethylpyrilamine |
Pyrilamine |
Metabolite |
|
9. |
2-(1-Hydroxyethyl) Promazine Sulfoxide |
Acepromazine |
Metabolite |
|
10. |
(1-Hydroxyethyl) Promazine (uncrystallized) |
Acepromazine |
Metabolite |
|
11. |
Promazine Sulfoxide |
Promazine |
Metabolite |
|
12. |
Promethazine Sulfoxide |
Promethazine |
Metabolite |
|
13. |
3-OH-Promazine |
Promazine |
Metabolite |
|
14. |
2-(1-Hydroxypropyl) Promazine Sulfoxide |
Propionylpromazine |
Metabolite |
|
15. |
4-OH-Propranolol |
Propranolol |
Metabolite |
|
16. |
3-OH-Tripelennamine |
Tripelennamine |
Derivative |
|
17. |
3-O-Methyl Colterol |
Colterol, Bitolterol |
Metabolite |
|
18. |
7-OH Chlorpromazine |
Chlorpromazine |
Metabolite |
|
19. |
Phenylbutazone-D9 |
Phenylbutazone |
Deuterated drug standard |
|
20. |
Procaine-D10 |
Procaine |
Deuterated drug standard |
|
21. |
Furosemide-D5 |
Furosemide |
Deuterated drug standard |
|
22. |
Clenbuterol-D9 |
Clenbuterol |
Standard |
| |
|
|
|
- Royalty Arrangements: "Drugs and the
Performance Horse" and "Equine Drugs and Vaccines: A Guide
for Owners and Trainers."
- Investigational New Animal Drugs: two fast track / no
environmental risk INADs for two agents for use in EPM. Patent
#5,883,095 granted in this area; licensed to Bayer Animal Health,
1999, marketed as Marquisâ , August,
2001.
- Other patent applications and intellectual properties in progress.
|