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THOMAS TOBIN PUBLICATIONS PRIOR TO JOINING
THE UNIVERSITY OF KENTUCKY    (Prior to 1975)
(These publications are not indexed)

  1. Post RL, Kume S, Tobin T, Orcutt B, Sen AK: Flexibility of an active centre in (Na++K+)-dependent ATPase. J Gen Physiol 54(1)Part 2:306-326, 1969.
  2. Sen AK, Tobin T, Post RL: A cycle for ouabain inhibition of the (Na++K+)-ATPase. J Biol Chem 244:6596-6604, 1969.
  3. Tobin T, Banerjee SP, Sen AK: Allosteric interactions in the (Na++K+)-ATPase. Nature 225:745, 1970.
  4. Tobin T, Sen AK: Stability and ligand sensitivity of [3H]-ouabain binding to the (Na++K+)-ATPase. Biochem Biophys Acta 198:120-131, 1970.
  5. Akera T, Hook JB, Tobin T, Brody TM: Cardiac glycoside sensitivity of (Na++K+)-activated ATPase in newborn rats. Res Commun Chem Pathol Pharmacol 4:599-706, 1972.
  6. Tobin, T, Baskin SI, Akera T, Brody TM: Nucleotide specificity of the (Na++K+)-dependent adenosine triphosphatase. Molec Pharmacol 8:256-263, 1972.
  7. Tobin T, Brody TM: Rates of dissociation of enzyme-oubain complexes and K0.5 values in (Na++K+)-adenosine triphosphatase from different species. Biochem Pharmacol 21:1553-1560, 1972.
  8. Tobin T, Henderson R, Sen AK: Species and tissue differences in the rate of dissociation of ouabain from the (Na++K+)-ATPase. Biochem Biophys Acta 274:551-555, 1972.
  9. Akera T, Baskin SI, Tobin T, Brody TM: Ouabain: Temporal relationship between the ionotropic effect and the in vitro binding to and dissociation from (Na++K+)-activated ATPase. Naunyn-Schmiedeberg's Archiv fur Pharmacol 277:151-162, 1973.
  10. Akera T, Rech RH, Marquis WJ, Tobin T, Brody TM: Lack of relationship between brain (Na++K+)-activated adenosine triphosphatase and the development of tolerance to ethanol in rats. J Pharmacol Exp Ther 185:594-601, 1973.
  11. Tobin T, Akera T, Baskin SI, Brody TM: Calcium and sodium and potassium dependent adenosine triphosphatase: Its mechanism of inhibition and identification of the EI-P intermediate. Mol Pharmacol 9:336-349, 1973.
  12. Tobin T, Akera T, Hogg RE, Brody TM: Ouabain binding to sodium- and potassium-dependent triphosphatase: Inhibition by the b-y-methylene analogue of adenosine triphosphatase. Mol Pharmacol 9:278-281, 1973.
  13. Tobin T, Akera T, Ku D, LU MC: Reversibility of the interaction of strophanthidin bromacetate with the cardiotonic steroid binding site of sodium- and potassium-dependent adenosine triphosphatase. Mol Pharmacol 9:676-685, 1973.
  14. Tobin T, Dirdjosudiono S, Baskin SI: Pharmacokinetics and distribution of diphenylhydantoin in kittens. Am J Vet Res 34:951-954, 1973.
  15. Akera T, Baskin SI, Tobin T, Brody TM: Cardiac glycosides: Temporal relationship between the inotropic action and binding to and dissociation from Na++K+-activated ATPase in vitro. Recent Advances in Studies on Cardiac Structure and Metabolism, Vol 4, Myocardial Biology (ed NS Dhalla), University Park Press, Baltimore, pp 139-147, 1974.
  16. Akera T, Baskin SI, Tobin T, Brody TM, Manian AA: 7-8-Dihydroxychlorpromazine: (Na++K+)-ATPase inhibition and positive inotropic effect. Advances in Biochem Psychopharmacol 9:633-640, 1974.
  17. Akera T, Brody TM, So RH-M, Tobin T, Baskin SI: Factors and agents that influence cardiac glycoside Na++K+-ATPase interaction. Ann NY Acad Sci 242:617-634, 1974.
  18. Akera T, Tobin T, Gatti A, Shieh I-S, Brody TM: Effect of potassium on the conformational state of the complex of ouabain with sodium- and potassium-dependent adenosine triphosphatase. Mol Pharmacol 10:509-518, 1974.
  19. Ku D, Akera T, Tobin T, Brody TM: Effects of rubidium on cardiac tissue Inhibition of Na ++K+-ATPase and stimulation of contractile force. Res Commun Chem Pathol Pharmacol 9: 431-440, 1974.
  20. Tobin T, Akera T, Baskin SI, Brody TM: The mechanism of the Ca++ ion inhibition of sodium-potassium ATPase. Recent Advances in Studies on Cardiac Structure and Metabolism. Vol. 4, Myocardial Biology (ed NS Dhalla), University Park Press, Baltimore, pp 139-147, 1974.
  21. Tobin T, Akera T, Brody TM: Studies on the two phosphoenzyme conformations of Na++K+-ATPase. Ann NY Acad Sci 242: 120-132, 1974.
  22. Tobin T, Akera T, Dworin JZ, Brody TM: Fluoride nephropathy: Lack of direct involvement of renal ATPase. Canad J Physiol Pharmacol 52:489-495, 1974.
  23. Tobin T, Akera T, Han CS, Brody TM: Lithium and rubidium interactions with sodium- and potassium-dependent adenosine triphosphatase: A molecular basis for the pharmacological actions of these ions. Mol Pharmacol 10:501-508, 1974.
  24. Tobin T, Akera T, Lee CY, Brody TM: Ouabain binding to (Na++K+)ATPase: Effects of nucleotide analogues and ethacrynic acid. Biochem Biophys Acta 354:102-117, 1974.
  25. Abramson HN, Huang CL, Wu TF, Tobin T: Thiocardenolides. I. Synthesis and biological actions of 3- -thiocyanato-14 -hydroxy-5- -card-20(22)-endide. J Pharm Sci 65:765-768, 1975.
  26. Ku D, Akera T, Tobin T, Brody TM: Effects of monovalent cations of cardiac Na++K+-ATPase activity and on contractile form. Naunyn-Schmiedeberg's Archiv fur Pharmacol 20: 113-131, 1975.
  27. Tobin T, Abramson H: Irreversible inhibition of [3H]-ouabain binding to Na++K+-ATPase by digoxigenin-3-12 di-bromacetate, an alkylating derivative of digoxigenin. Eur J Pharmacol 32: 243-250, 1975.
  28. Tobin T, Akera T: Shaodowmycin, a nucleotide site directed inhibitor of Na++K+-ATPase. Biochem Biophys Acta 389: 126-136, 1975.
  29. Tobin T, Akera T, Brody SI, Brody TM: The mechanism of interaction of cassaine with Na++K+-ATPase. Biochemical Soc Transactions 2:1375-1378, 1975.
  30. Tobin T, Akera T, Brody TM: Gel electrophoretic identity of the Na+, Mg++, and Na+Ca++-stimulated phosphorylations of Na+K+-ATPase. Biochem Biophys Acta 393, 117-125, 1975.
  31. Tobin T, Akera T, Brody TM, Tanaja HA: Irreversible inhibition of Na++K+-ATPase: Strophanthidin 3,5-bisparabenzoylbenzoate, a photo-chemical analog of strophanthidin. Res Commun Chem Pathol Pharmacol 10: 605-617, 1975.
  32. Akera T, Ku D, Tobin T, Brody TM: The complexes of ouabain with sodium- and potassium-activated adenosine triphosphatase formed with various ligands: The relationship to the complex formed in the beating heart. Mol Pharmacol 12:101-114, 1976.
  33. Han CS, Tobin T, Brody TM: Effects of monovalent cations on E-P32 and [3H]-ouabain binding of Na++K+-ATPase. Biochem Biophys Acta 429:993-1005, 1976.
  34. Ku D, Akera T, Tobin T, Brody TM: Comparative species studies on the effects of monovalent cations and ouabain on cardiac Na++K+-ATPase and contractile force. J Pharm Exp Therap 197(2):458-469, 1976.
  35. Tobin T, Akera T, Han CS, Brody TM: Studies on the stable inhibition of Na++K+-ATPase by cassaine. Eur J Pharmacol 35: 59-68, 1976.
  36. Tobin T, Akera T, Taneja HA, Brody TM: Cardiotonic site directed irreversible inhibition of Na++K+-ATPase by 3-azidoacetyl-strophanthidin, a photochemical analogue of strophanthidin. Eur J Pharmacol 35:68-76, 1976.